Critical, existence-threatening, or fatal respiratory melancholy has actually been documented with the usage of opioids, which includes codeine, among the list of Energetic substances in Promethazine HCl and Codeine Phosphate Oral Remedy. Codeine makes dose-relevant respiratory depression by immediately performing about the brain stem respiratory Centre that controls respiratory rhythm and could generate irregular and periodic respiration. Codeine is issue to variability in metabolism based upon CYP2D6 genotype, which may result in an increased publicity for the active metabolite morphine [see Warnings and Safeguards (5.three)]. Promethazine exerts a depressant effect on the respiratory Middle that is certainly independent of and additive to that of other respiratory depressants, including codeine [see Warnings and Safety measures (5.
Sedating prescription drugs may possibly trigger confusion and about-sedation in the aged; aged sufferers generally really should be started off on very low doses of Promethazine HCl Oral Option and noticed closely.
Antihistamines and codeine are each contraindicated to be used in the cure of lessen respiratory tract indicators, like bronchial asthma.
Promethazine hydrochloride happens as a white to faint yellow, virtually odorless, crystalline powder which little by little oxidizes and turns blue on extended exposure to air.
Promethazine HCl Oral Remedy and selected other medicines can interact with one another. Convey to your Health care Experienced about all of the medicines you take including prescription and non-prescription medicines, natural vitamins, and herbal supplements.
The mix of promethazine hydrochloride and codeine phosphate must be used with warning in pediatric individual 6 many years and older (see WARNINGS – Use in Pediatric Patients).
Promethazine really should not be used in pediatric people lower than two decades of age due to the likely for deadly respiratory despair.
Codeine in oral therapeutic dosage will not usually exert big outcomes on the cardiovascular process.
Cure of Overdose Procedure of overdosage is driven by the overall medical presentation, and includes discontinuation of Promethazine HCl and Codeine Phosphate Oral Resolution together with institution of proper therapy. Give Principal interest to your reestablishment of suitable respiratory exchange by way of provision of a patent and protected airway plus the institution of assisted or controlled ventilation.
Promethazine: Indications and signs and symptoms of overdosage with promethazine HCl range between mild melancholy of the central anxious process and cardiovascular process to profound hypotension,
The combination of promethazine read more hydrochloride and codeine phosphate is contraindicated in pediatric patients under 6 many years of age, due to the fact The mix may well bring about deadly respiratory despair On this age inhabitants. It is necessary that promethazine hydrochloride and codeine phosphate syrup is measured with an correct measuring product (see Safety measures-Info for Patients).
Treatment: The treatment of overdosage with promethazine and codeine is basically symptomatic and supportive. Only in circumstances of extreme overdosage or specific sensitivity do critical signals which includes respiration, pulse, blood pressure, temperature, and EKG have to be monitored. Activated charcoal orally or by lavage can be specified, or sodium or magnesium sulfate orally as being a cathartic. Notice ought to be specified to the reestablishment of suitable respiratory Trade by provision of a patent airway and establishment of assisted or controlled air flow.
Postmarketing cases of respiratory melancholy, including fatalities are noted with utilization of promethazine in pediatric individuals.
Offering or giving away Promethazine Hydrochloride and Codeine Phosphate Oral Option could hurt Other folks, and is from the law. Explain to your Health care supplier if you have ever abused or been depending on Liquor, prescription medicines or Road drugs.